Lofexidine

• Description :

  Lofexidine is a selective α2-receptor agonist, commonly used to alleviate the physical symptoms of heroin and other types of opioid withdrawal[1][2].

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H315, H319, H335

• Target :

  Adrenergic Receptor

• Type :

  Reference compound

• Related Pathways :

  GPCR/G Protein; Neuronal Signaling

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Neurological Disease; Endocrinology

• Assay Protocol :

  https://www.medchemexpress.com/Lofexidine.html

• Purity :

  99.08

• Solubility :

  DMSO : 62.5 mg/mL (ultrasonic)

• Smiles :

  CC(C1=NCCN1)OC2=C(Cl)C=CC=C2Cl

• Molecular Formula :

  C11H12Cl2N2O

• Molecular Weight :

  259.13

• Precautions :

  H302, H315, H319, H335

• References & Citations :

  [1]Vartak AP, et al. The preclinical discovery of lofexidine for the treatment of opiate addiction. Expert Opin Drug Discov. 2014 Nov;9 (11) :1371-7.|[2]Gish EC, et al. Lofexidine, an {alpha}2-receptor agonist for opioid detoxification. Ann Pharmacother. 2010 Feb;44 (2) :343-51.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  Launched

• Isoform :

  α adrenergic receptor

• CAS Number :

  [31036-80-3]