HIF-1α-IN-5

• UNSPSC Description:

  HIF-1α-IN-5 is a HIF-1α inhibitor with an IC50 value of 24 nM (in HEK293T cell). HIF-1α-IN-5 also inhibits MAO-A activity. HIF-1α-IN-5 downregulates VEGF and PDK1 mRNA expressions under hypoxia. HIF-1α-IN-5 can be used in the research of cancer[1].

• Target Antigen:

  HIF/HIF Prolyl-Hydroxylase; Monoamine Oxidase

• Type:

  Reference compound

• Related Pathways:

  Metabolic Enzyme/Protease;Neuronal Signaling

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/hif-1α-in-5.html

• Solubility:

  DMSO : 125 mg/mL (ultrasonic)

• Smiles:

  O=C(C1=NOC2=CC=CC=C12)NC3=CC=C(N(C)C)C=C3

• Molecular Weight:

  281.31

• References & Citations:

  [1]Zian Xue, et al. Benzo[d]isoxazole Derivatives as Hypoxia-Inducible Factor (HIF)-1α Inhibitors. ACS Med. Chem. Lett. 2022.

• Shipping Conditions:

  Blue Ice

• Clinical Information:

  No Development Reported

• CAS Number:

  2826221-10-5