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[8]-Shogaol

CAT: 0804-HY-N2435-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-N2435-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
[8]-Shogaol, a kind of stimulating compound in ginger, has antiplatelet (IC50=5 μM), anti-cancer and anti-inflammatory activity. [8]-Shogaol inhibited COX-2 (IC50=17.5 μM), which led to the decline of human leukemia cells. 8-Shogaol Selective direction TAK1 sum TAK1-TAB1 (IC50=5 μM), suppress IKK, Akt sum MAPK signal pathway, and reverse synovitis synovial sum Air dampness (RA) [1][2][3][4].
CAS Number
36700-45-5
UNSPSC
12352005
Hazard Statement
H302
Target
Apoptosis; COX
Type
Natural Products
Related Pathways
Apoptosis; Immunology/Inflammation
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/8-shogaol.html
Purity
99.93
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CCCCCCC/C=C/C(CCC1=CC=C(O)C(OC)=C1)=O
Molecular Formula
C19H28O3
Molecular Weight
304.42
Precautions
H302
References & Citations
[1]Shieh PC, et al. Induction of apoptosis by [8]-shogaol via reactive oxygen species generation, glutathione depletion, and caspase activation in human leukemia cells. J Agric Food Chem. 2010 Mar 24;58 (6) :3847-54.|[2]van Breemen RB, et al. Cyclooxygenase-2 inhibitors in ginger (Zingiber officinale) . Fitoterapia. 2011 Jan;82 (1) :38-43.|[3]Nurtjahja-Tjendraputra E, et al. Effective anti-platelet and COX-1 enzyme inhibitors from pungent constituents of ginger. Thromb Res. 2003;111 (4-5) :259-65.|[4]Jo S, et al. 8-Shogaol inhibits rheumatoid arthritis through targeting TAK1. Pharmacol Res. 2022 Apr;178:106176.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
COX-2

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