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[10]-Shogaol

CAT: 0804-HY-N2434-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-N2434-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
[10]-Shogaol is an orally active antioxidant. [10]-Shogaol can be extracted from ginger (Zingiber officinale). [10]-Shogaol1 inhibits COX-2 with an IC50 value of 7.5 μM. [10]-Shogaol inhibits the production of proinflammatory cytokines (IL-1β, IL-6). [10]-Shogaol inhibits NF-κB phosphorylation. [10]-Shogaol has anti-inflammatory effects. [10]-Shogaol has anticancer effects against Docetaxel -resistant prostate cancer. [10]-Shogaol exhibits larvicidal activity against L5 larvae of Angiostrongylus cantonensis[1][2][3][4][5].
CAS Number
36752-54-2
UNSPSC
12352005
Hazard Statement
H302
Target
COX; Interleukin Related; NF-κB; Parasite
Type
Natural Products
Related Pathways
Anti-infection; Immunology/Inflammation; NF-κB
Applications
Cancer-programmed cell death
Field of Research
Cancer; Infection; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/10-shogaol.html
Purity
99.78
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CCCCCCCCC/C=C/C(CCC1=CC=C(O)C(OC)=C1)=O
Molecular Formula
C21H32O3
Molecular Weight
332.48
Precautions
H302
References & Citations
[1]Chen CY, et al. 10-Shogaol, an antioxidant from Zingiber officinale for skin cell proliferation and migration enhancer. Int J Mol Sci. 2012;13 (2) :1762-77.|[2]van Breemen RB, et al. Cyclooxygenase-2 inhibitors in ginger (Zingiber officinale) . Fitoterapia. 2011 Jan;82 (1) :38-43.|[3]Liu CM, et al. Ginger Phytochemicals Inhibit Cell Growth and Modulate Drug Resistance Factors in Docetaxel Resistant Prostate Cancer Cell. Molecules. 2017 Sep 5;22 (9) . pii: E1477.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
COX-2; IL-1; IL-6

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