Shogaol

• Target:

  Autophagy|||Lipoxygenase

• Related Pathways:

  Metabolism|||Autophagy

• Purity:

  0.9993

• Bioactivity:

  1. 6-Shogaol (6-Shogaol) has antipyretic and analgesic effects in addition to inhibitory effect on lipoxygenase activity. 2. 6-shogaol has anti-inflammatory property, reduces the inflammatory response and protected the femoral cartilage from damage produced in a CFA monoarthritic model of the knee joint of rats. 3. 6-Shogaol inhibits the growth of human cancer cells and induces apoptosis in COLO 25 cells through modulation of mitochondrial functions regulated by reactive oxygen species (ROS) . 4. 6-Shogaol effectively inhibit invasion and metastasis of hepatocellular carcinoma through diverse molecular mechanisms, including inhibition of the MAPK and PI3k/Akt pathways and NF-?B and STAT3 activities to suppress expression of MMP-2/-9 and uPA and block angiogenesis, could further regulate urokinase-type plasminogen activity.

• Smiles:

  CCCCC\C=C\C (=O) CCc1ccc (O) c (OC) c1

• Molecular Formula:

  C17H24O3

• Molecular Weight:

  276.37

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  555-66-8