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Shogaol

CAT: 0931-T6S1699-01Size: 2 mgDry Ice: NoHazardous: No
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CAT#:0931-T6S1699-01Size:2 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
555-66-8
Target
Autophagy, Lipoxygenase
Related Pathways
Metabolism, Autophagy
Purity
0.9993
Bioactivity
1. 6-Shogaol (6-Shogaol) has antipyretic and analgesic effects in addition to inhibitory effect on lipoxygenase activity. 2. 6-shogaol has anti-inflammatory property, reduces the inflammatory response and protected the femoral cartilage from damage produced in a CFA monoarthritic model of the knee joint of rats. 3. 6-Shogaol inhibits the growth of human cancer cells and induces apoptosis in COLO 25 cells through modulation of mitochondrial functions regulated by reactive oxygen species (ROS) . 4. 6-Shogaol effectively inhibit invasion and metastasis of hepatocellular carcinoma through diverse molecular mechanisms, including inhibition of the MAPK and PI3k/Akt pathways and NF-κB and STAT3 activities to suppress expression of MMP-2/-9 and uPA and block angiogenesis, could further regulate urokinase-type plasminogen activity.
Smiles
CCCCC\C=C\C(=O)CCc1ccc(O)c(OC)c1
Molecular Formula
C17H24O3
Molecular Weight
276.37
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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