RegisterLogin

Beta-Lapachone

CAT: 0400-SIH-589-25MGSize: 25 mgDry Ice: NoHazardous: No
CAT#:0400-SIH-589-25MGSize:25 mg
Selected
PRICE
AVAILABILITY
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Background
β-Lapachone is a naturally occurring quinone obtained from the bark of the lapacho tree (Tabebuia avellanedae) with cancer chemopreventive properties. A novel DNA topoisomerase I inhibitor which unlike camptothecin does not stabilize the cleavable complex indicating a novel mode of action (1). Induces apoptosis in a number of cancer cell lines (2). In cancer cells overexpressing NAD(P)H:quinone oxidoreductase, reduction of β-lapachone leads to futile cycling between quinone and hydroquinone forms (3) resulting in the production of reactive oxygen species (4). Suppresses radiation-induced activation of NFĸB (5). Attenuates cognitive impairment and inflammation in amyloid-induced mouse model.
Description
DNA topoisomerase I inhibitor
CAS Number
4707-32-8
Product Name Alternative
3,4-Dihydro-2,2-dimethyl-2H-naphtho[1,2-b]pyran-5,6-dione; NSC-26326
UNSPSC
41116105
Type
Inhibitor
Source
Synthetic
Field of Research
Cell Signaling | Epigenetics and Nuclear Signaling | DNA/RNA | DNA Synthesis | Topoisomerases | Neuroscience | Neurodegeneration | Alzheimer's Disease
Purity
>98% (HPLC) ; NMR (Conforms)
Weight
0.005
Format
Orange powder
Solubility
May be dissolved in DMSO (35 mg/ml); or Ethanol (15 mg/ml)
Molecular Formula
C15H14O3
Molecular Weight
242.3
Precautions
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
References & Citations
1. CJ Li et al. J. Biol. Chem. 1993 268:22463 2. SM Wuerzberger et al. Cancer Res. 1998 58:1876 3. JJ Pink et al. J. Biol. Chem. 2000 275:5416 4. D Siegel et al. Biochem. Pharmacol. 2012 83:1033 5. GZ Dong et al. Exp. Mol. Med. 2010 42:327

Related Products

CatalogName
SPR-405CBeta Synuclein Monomers
SMC-241SENaC beta Antibody
SPR-102AHSP90 beta Protein
SPR-405EBeta Synuclein Monomers
SPC-404DENaC beta Antibody
SPR-102CHSP90 beta Protein
SMC-241DENaC beta Antibody
SPR-102BHSP90 beta Protein
SPC-404SENaC beta Antibody
SPR-405BBeta Synuclein Monomers

Alternative Products

CatalogName
M18579-01Beta-Lapachone
MBS8005959-01Beta-Lapachone
abx076869-01Beta-Lapachone
BISN0149-01Beta-Lapachone
B2290-10Beta-Lapachone
B2290-50Beta-Lapachone
MBS6052185-01beta-Lapachone
C12556-01Beta-Lapachone
B2290-5.1Beta-Lapachone
MBS3608573-01Beta-Lapachone

Popular Products