Beta Synuclein Monomers

CAT: 0400-SPR-405CSize: 2x 100 µgDry Ice: YesHazardous: No
CAT#:0400-SPR-405CSize:2x 100 µg
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PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Alzheimer’s Disease (AD) is the most common neurodegenerative disease, affecting 10% of seniors over the age of 65 (1) . It was named after Alois Alzheimer, a German scientist who discovered tangled bundles of fibrils where neurons had once been in the brain of a deceased patient in 1907 (2) . Beta synuclein is abundant in neurofibrillary lesions of patients with Alzheimer's Disease. Beta synuclein is suggested to be an inhibitor of alpha synuclein aggregation- protecting the central nervous system from the neurotoxin effects of alpha synuclein (3) .
Description
Human Recombinant Beta Synuclein Monomers
Product Name Alternative
14 kDa brain-specific protein, Beta-synuclein Protein, Phosphoneuroprotein 14 Protein, PNP14 Protein, Sncb Protein, Synuclein beta Protein, SYUB_HUMAN Protein
UNSPSC
12352202
UN Code
Non-hazardous
Hazard Statement
Non-hazardous
Gene ID
6620
Swiss Prot
Q16143
Accession Number
NP_001001502.1
Cellular Locus
Cytoplasm
Expression System
E. coli
Host
E. coli
Origin Species
Human
Target
Beta Synuclein
Conjugation
No tag
Nature
Recombinant
Applications
WB | SDS-PAGE | In vivo assay | In vitro assay
Field of Research
Neuroscience | Neurodegeneration | Alzheimer's Disease | Tangles & Tau | Neuroscience | Neurodegeneration | Parkinson's Disease | Synuclein
Purification Method
Ion-exchange Purified
Purification
Ion-exchange Purified
Limit Of Detection
Certified >95% pure using SDS-PAGE analysis. Low endotoxin <5 EU/mL @ 2mg/mL.
Concentration
2 mg/ml
Purity
>95%
Weight
0.2
Length
Full length
Buffer
PBS pH 7.4
Molecular Weight
14.28 kDa
Precautions
Not for use in humans. Not for use in diagnostics or therapeutics. For research use only.
Additionnal Information
For corresponding PFFs, see catalog# SPR-457
References & Citations
1. www.alz.org/alzheimers-dementia/facts-figures 2. Alzheimer, A. Über eine eigenartige Erkrankung der Hirnrinde. Allg. Z. Psychiatr. Psych.-Gerichtl. Med. 64, 146–148 (1907). 3. Taschenberger G., et al. (2013) Ann Neurol. 74(1): 109-118.
Shipping Conditions
Dry Ice. Shipping note: Product will be shipped separately from other products purchased in the same order.
Storage Conditions
-80ºC
Notes
For corresponding PFFs, see catalog# SPR-457
Protein Length
Full length
Background Reference 01
1. www.alz.org/alzheimers-dementia/facts-figures 2. Alzheimer, A. Über eine eigenartige Erkrankung der Hirnrinde. Allg. Z. Psychiatr. Psych.-Gerichtl. Med. 64, 146–148 (1907) . 3. Taschenberger G., et al. (2013) Ann Neurol. 74 (1) : 109-118.
Location
Cytoplasm
Immunogen Species
Human
Product MSDS
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