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LMP517

CAT: 0804-HY-160005-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-160005-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
LMP517 (NSC 781517) is a potent and non-camptothecin Topoisomerase I and II (TOP1 and TOP2) dual inhibitor. LMP517 can induce TOP1 and TOP2 cleavage complexes (TOP1ccs and TOP2ccs) . LMP517 can induce cancer cells DNA damage and γH2AX production. LMP517 can be used for the research of cancer, such as small cell lung cancer[1][2].
CAS Number
1883730-99-1
Product Name Alternative
NSC 781517
UNSPSC
12352005
Target
DNA/RNA Synthesis; Topoisomerase
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/lmp517.html
Purity
99.58
Solubility
DMSO : 44 mg/mL (ultrasonic; adjust pH to 1 with TFA)
Smiles
O=C1C2=CC3=C(C=C2C4=C1C5=C(C(N4CCCNCCO)=O)C=C(F)C=C5)OCO3
Molecular Formula
C22H19FN2O5
Molecular Weight
410.40
References & Citations
[1]Marzi L, et al. The Indenoisoquinoline LMP517: A Novel Antitumor Agent Targeting both TOP1 and TOP2. Mol Cancer Ther. 2020 Aug;19 (8) :1589-1597.|[2]Marzi L, et al. Novel Fluoroindenoisoquinoline Non-Camptothecin Topoisomerase I Inhibitors. Mol Cancer Ther. 2018 Aug;17 (8) :1694-1704.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Topo I; Topo II

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