Anti-Hu CD270 APC

• Description:

  CD270 is a type I transmembrane protein of the TNFR superfamily, which is expressed on resting T cells, monocytes, and immature dendritic cells. Its ligands, CD258 and CD272, differ in effect on CD270 signaling. Whereas binding to CD258 provides a costimulatory signal, binding to CD272 gives to the cell an inhibitory signal. CD270 also is recognized by herpes simplex glycoprotein D. CD258-CD270 interaction and signaling is implicated in macrophage-derived foam cell-mediated development of atherosclerotic lesions.

• Certification:

  RUO

• Reactivity:

  Human

• Immunogen:

  Recombinant human CD270

• Target Antigen:

  CD270

• Clone:

  CW10

• Applications:

  FC (QC tested)

• Format:

  APC

• Buffer:

  Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

• References & Citations:

  *Whitbeck JC, Connolly SA, Willis SH, Hou W, Krummenacher C, de Leon MP, Lou H, Baribaud I, Eisenberg RJ, Cohen GH: Localization of the gD-binding region of the human herpes simplex virus receptor, HveA. J Virol. 2001 Jan;75 (1) :171-80., URL: https://pubmed.ncbi.nlm.nih.gov/11119586/, *Stiles KM, Whitbeck JC, Lou H, Cohen GH, Eisenberg RJ, Krummenacher C: Herpes simplex virus glycoprotein D interferes with binding of herpesvirus entry mediator to its ligands through downregulation and direct competition. J Virol. 2010 Nov;84 (22) :11646-60. , URL: https://pubmed.ncbi.nlm.nih.gov/20826693/, *Bender FC, Whitbeck JC, Ponce de Leon M, Lou H, Eisenberg RJ, Cohen GH: Specific association of glycoprotein B with lipid rafts during herpes simplex virus entry. J Virol. 2003 Sep;77 (17) :9542-52. , URL: https://pubmed.ncbi.nlm.nih.gov/12915568/

• Storage Conditions:

  Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.

• Specificity:

  The mouse monoclonal antibody CW10 recognizes an extracellular epitope on CD270, a type I transmembrane protein expressed on resting T cells, monocytes, and immature dendritic cells.

• Applications Notes:

  6

• Isotype:

  Mouse IgG1 kappa