Anti-Hu CD270 Purified

Anti-Hu CD270 Purified

• Background: CD270 is a type I transmembrane protein of the TNFR superfamily, which is expressed on resting T cells, monocytes, and immature dendritic cells. Its ligands, CD258 and CD272, differ in effect on CD270 signaling. Whereas binding to CD258 provides a costimulatory signal, binding to CD272 gives to the cell an inhibitory signal. CD270 also is recognized by herpes simplex glycoprotein D. CD258-CD270 interaction and signaling is implicated in macrophage-derived foam cell-mediated development of atherosclerotic lesions.
• Specifications: The mouse monoclonal antibody CW10 recognizes an extracellular epitope on CD270, a type I transmembrane protein expressed on resting T cells, monocytes, and immature dendritic cells.
• CAS Number: 9007-83-4
• Certification: RUO
• Host: Mouse
• Species Reactivity: Human
• Immunogen: recombinant human CD270
• Target Antigen: CD270
• Isotype: Igg1 κ
• Clone: CW10
• Applications: Flow cytometry: Recommended dilution: 1-5 μg/mL.
• Validated Applications: WB, ICC, FC, ELISA, IP
• Concentration: 1 mg/mL
• Format: Purified
• Buffer: Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
• References & Citations: *Whitbeck JC, Connolly SA, Willis SH, Hou W, Krummenacher C, de Leon MP, Lou H, Baribaud I, Eisenberg RJ, Cohen GH: Localization of the gD-binding region of the human herpes simplex virus receptor, HveA. J Virol. 2001 Jan75(1):171-80., URL: https://pubmed.ncbi.nlm.nih.gov/11119586/,*Stiles KM, Whitbeck JC, Lou H, Cohen GH, Eisenberg RJ, Krummenacher C: Herpes simplex virus glycoprotein D interferes with binding of herpesvirus entry mediator to its ligands through downregulation and direct competition. J Virol. 2010 Nov84(22):11646-60. , URL: https://pubmed.ncbi.nlm.nih.gov/20826693/,
• Storage Conditions: Store at 2-8°C. Do not freeze.