AI-10-49

CAT: 0804-HY-16786-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-16786-01Size:5 mg
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Description
AI-10-49 is an inhibitor of leukemic oncoprotein CBFβ-SMHHC. AI-10-49 inhibits the binding of CBFβ-SMMHCto the RUNX1 Runt domain with IC50 value of 0.26 μM. AI-10-49 can be used for the research of leukemia[1].
CAS Number
[1256094-72-0]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
RUNX
Type
Reference compound
Related Pathways
Stem Cell/Wnt; TGF-beta/Smad
Applications
Cancer-programmed cell death
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/AI-10-49.html
Purity
99.24
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
FC(F)(F)OC1=CC=C2N=C(C3=NC=C(OCCOCCOC4=CN=C(C5=NC6=CC=C(OC(F)(F)F)C=C6N5)C=C4)C=C3)NC2=C1
Molecular Formula
C30H22F6N6O5
Molecular Weight
660.52
Precautions
H302, H315, H319, H335
References & Citations
[1]Anuradha Illendula, et al. Chemical biology. A small-molecule inhibitor of the aberrant transcription factor CBFβ-SMMHC delays leukemia in mice. Science. 2015 Feb 13;347 (6223) :779-84.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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