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AI-4-57

CAT: 0804-HY-125966-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-125966-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
AI-4-57 is an allosteric inhibitor for CBFβ SMMHC-RUNX1 (core binding factor β and the smooth-muscle myosin heavy chain) interaction with an IC50 of 22 μM[1].
CAS Number
63053-14-5
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
RUNX
Type
Reference compound
Related Pathways
Stem Cell/Wnt; TGF-beta/Smad
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ai-4-57.html
Smiles
COC1=CC=C2N=C(C3=NC=CC=C3)NC2=C1
Molecular Formula
C13H11N3O
Molecular Weight
225.25
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362-P403+P233-P405-P501
References & Citations
[1]Illendula A, et al., A small-molecule inhibitor of the aberrant transcription factor CBFβ-SMMHC delays leukemia in mice. Science. 2015 Feb 13;347 (6223) :779-84.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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