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BPTU

CAT: 0804-HY-13831-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-13831-01Size:5 mg
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AVAILABILITY: InStock
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Description
BPTU (BMS-646786) is a non-nucleotide P2Y1 receptor allosteric antagonist with antithrombotic activity. BPTU is able to block the P2Y1 receptor located at the neuromuscular junction of the gastrointestinal tract[1][2].
CAS Number
[870544-59-5]
Product Name Alternative
BMS-646786
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
P2Y Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
Cancer-programmed cell death
Field of Research
Cancer; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/BPTU.html
Purity
99.67
Solubility
DMSO : ≥ 33.3 mg/mL
Smiles
O=C(NC1=CC=C(OC(F)(F)F)C=C1)NC2=CC=CN=C2OC3=CC=CC=C3C(C)(C)C
Molecular Formula
C23H22F3N3O3
Molecular Weight
445.43
Precautions
H302, H315, H319, H335
References & Citations
[1]Noemí Mañé, et al. BPTU, an allosteric antagonist of P2Y1 receptor, blocks nerve mediated inhibitory neuromuscular responses in the gastrointestinal tract of rodents. Neuropharmacology. 2016 Nov;110 (Pt A) :376-385.|[2]Dandan Zhang, et al. Two disparate ligand binding sites in the human P2Y1 receptor. Nature. 2015 Apr 16; 520 (7547) : 317–321.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
P2Y1 Receptor

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