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BPTQ

CAT: 0804-HY-124122Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-124122Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
BPTQ is a potent inhibitor against VEGFR1 and CHK2 with IC50 values of 0.54 and 1.70 µmol/L, respectively. BPTQ is also an intercalator of DNA with anticancer activities. BPTQ inhibits the proliferation of HL-60 cells by arresting cells at S and G2/M phase with an IC50 value of 12 µmol/L. BPTQ also activates the mitochondria-mediated Apoptosis pathway by a decrease in mitochondrial membrane potential, increase in the Bax:Bcl-2 ratio and activation of caspases[1][2].
CAS Number
[1802665-43-5]
UNSPSC
12352005
Target
Apoptosis; Bcl-2 Family; Caspase; Checkpoint Kinase (Chk) ; VEGFR
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/bptq.html
Smiles
CCCCNC1=NC=NC2=C1SC3=C2C=C4C=CC=CC4=N3
Molecular Formula
C17H16N4S
Molecular Weight
308.40
References & Citations
[1]RohitKumar HG, et al. DNA intercalative 4-butylaminopyrimido[4',5':4,5]thieno (2,3-b) quinoline induces cell cycle arrest and apoptosis in leukemia cells. Cancer Chemother Pharmacol. 2015 Jun;75 (6) :1121-33.|[2]Rohit Kumar H, et al. Inhibition of protein kinases by anticancer DNA intercalator, 4-butylaminopyrimido[4',5':4,5]thieno (2,3-b) quinoline. Acta Pharm Sin B. 2017 May;7 (3) :303-310.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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