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Nicergoline (Standard)

CAT: 0804-HY-B0702R-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-B0702R-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Nicergoline (Standard) is the analytical standard of Nicergoline. This product is intended for research and analytical applications. Nicergoline, an ergoline derivative ester of bromonicotinic acid, is a potent, selective and orally active antagonist of α1A-adrenoceptor. Nicergoline has vasodilator effects. Nicergoline also has ameliorative effects on cognitive function in mouse models of Alzheimer's disease[1][2].
CAS Number
27848-84-6
UNSPSC
12352005
Target
Adrenergic Receptor; Reference Standards
Type
Reference Standards
Related Pathways
GPCR/G Protein; Neuronal Signaling; Others
Field of Research
Neurological Disease; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/nicergoline-standard.html
Smiles
CO[C@@]([C@@]1([H])C2)(C[C@@H](COC(C3=CN=CC(Br)=C3)=O)CN1C)C4=C5C2=CN(C)C5=CC=C4
Molecular Formula
C24H26BrN3O3
Molecular Weight
484.39
References & Citations
[1]Alvarez-Guerra, M., N. Bertholom, and R.P. Garay, Selective blockade by nicergoline of vascular responses elicited by stimulation of alpha 1A-adrenoceptor subtype in the rat. Fundam Clin Pharmacol, 1999. 13 (1) : p. 50-8.|[2]Zang G, et, al. Ameliorative effect of nicergoline on cognitive function through the PI3K/AKT signaling pathway in mouse models of Alzheimer's disease. Mol Med Rep. 2018 May;17 (5) :7293-7300.|[3]Mizuno T, et, al. Protective effects of nicergoline against neuronal cell death induced by activated microglia and astrocytes. Brain Res. 2005 Dec 20;1066 (1-2) :78-85.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
Clinical Information
Launched

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