Nicergoline

CAT: 0804-HY-B0702-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-B0702-01Size:5 mg
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
Nicergoline, an ergoline derivative ester of bromonicotinic acid, is a potent, selective and orally active antagonist of α1A-adrenoceptor. Nicergoline has vasodilator effects. Nicergoline also has ameliorative effects on cognitive function in mouse models of Alzheimer's disease[1][2].
CAS Number
[27848-84-6]
UNSPSC
12352005
Hazard Statement
H302
Target
Adrenergic Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/nicergoline.html
Concentration
10mM
Purity
99.31
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CO[C@@]([C@@]1([H])C2)(C[C@@H](COC(C3=CN=CC(Br)=C3)=O)CN1C)C4=C5C2=CN(C)C5=CC=C4
Molecular Formula
C24H26BrN3O3
Molecular Weight
484.39
Precautions
H302
References & Citations
[1]Alvarez-Guerra, M., N. Bertholom, and R.P. Garay, Selective blockade by nicergoline of vascular responses elicited by stimulation of alpha 1A-adrenoceptor subtype in the rat. Fundam Clin Pharmacol, 1999. 13 (1) : p. 50-8.|[2]Zang G, et, al. Ameliorative effect of nicergoline on cognitive function through the PI3K/AKT signaling pathway in mouse models of Alzheimer's disease. Mol Med Rep. 2018 May;17 (5) :7293-7300.|[3]Mizuno T, et, al. Protective effects of nicergoline against neuronal cell death induced by activated microglia and astrocytes. Brain Res. 2005 Dec 20;1066 (1-2) :78-85.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
α adrenergic receptor

Related Products

CatalogName

Alternative Products

CatalogName
MBS3603849-01Nicergoline
RM-N091800-01Nicergoline (Rrs)
255985Nicergoline discontinued
MBS5766686Nicergoline tartrate
A17422-10Nicergoline 10mg
A17422-25Nicergoline 25mg
A17422-200Nicergoline 200mg
TRC-N394552-1MGNicergoline-d3
A17422-50Nicergoline 50mg
A17422-100Nicergoline 100mg

Popular Products