Anti-Ms CD49e FITC

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E16FHF049e-025	FITC anti-human CD49e

Anti-Ms CD49e FITC

CAT:

270-1F-743-C100

Size:

0.1 mg

Price:

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Anti-Ms CD49e FITC

Background: CD49e, the alpha 5 integrin, noncovalently associates with the beta 1integrin (CD29) to form VLA-5 integrin complex. CD49e itself is composed of two disulfide-linked chains of 135 kDa and 25 kDa. VLA-5 binds to RGD sequence of fibronectin, and to neural adhesion molecule L1. It is important in maintaining the integrity of endothelial monolayers, in monocyte migration into the extracellular tissues, and it also provides a co-stimulatory signal to T cells and enhances receptor and complement receptor-mediated phagocytosis.
Specifications: The rat monoclonal antibody 5H10-27 (MFR5) recognizes an extracellular epitope of murine CD49e, a 135 kDa protein serving as VLA-5 alpha chain, expressed on thymocytes, activated T cells, splenic B cells, and mast cells.
Certification: RUO
Host: Rat
Species Reactivity: Mouse
Immunogen: C57BL/6 x A/J)F1 murine mast cell line
Target Antigen: CD49e
Isotype: IgG2a κ
Clone: 5H10-27 (MFR5)
Applications: Flow cytometry: Recommended dilution: 1-4 μg/mL.
Validated Applications: FC
Concentration: 0.5 mg/mL
Format: FITC
Buffer: Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
References & Citations: *van der Loo JC, Xiao X, McMillin D, Hashino K, Kato I, Williams DA: VLA-5 is expressed by mouse and human long-term repopulating hematopoietic cells and mediates adhesion to extracellular matrix protein fibronectin. J Clin Invest. 1998 Sep 1102(5):1051-61., URL: https://pubmed.ncbi.nlm.nih.gov/9727075/,*Sampaio AL, Zahn G, Leoni G, Vossmeyer D, Christner C, Marshall JF, Perretti M: Inflammation-dependent alpha 5 beta 1 (very late antigen-5) expression on leukocytes reveals a functional role for this integrin in acute peritonitis. J Leukoc Biol. 2010 May87(5):877-84., URL: https://pubmed.ncbi.nlm.nih.gov/20097849/,*Plett PA, Frankovitz SM, Orschell CM: Distribution of marrow repopulating cells between bone marrow and spleen early after transplantation. Blood. 2003 Sep 15102(6):2285-91., URL: http://www.ncbi.nlm.nih.gov/pubmed/12775569 ,
Storage Conditions: Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.

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1F-743-C100	Anti-Ms CD49e FITC
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10-743-C100	Anti-Ms CD49e Purified Azide Free
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