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Anti-HDAC6 Purified

CAT: 0270-11-839-C100Size: 0.1 mgDry Ice: NoHazardous: No
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CAT#:0270-11-839-C100Size:0.1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Histone deacetylase 6 (HDAC6), like other histone deacetylases, affects gene expression by regulation of chromatin remodeling. HDAC6 contains an internal duplication of two catalytic domains which appear to function independently of each other. Besides histones, HDAC6 deacetylates also other substrates including alpha tubulin and HSP90 alpha, and is involved in protein trafficking and degradation, as well as in affecting of cell shape and migration. Deregulation of HDAC6 expression and activity is associated with many diseases.
Certification
RUO
Reactivity
Human
Immunogen
Human HDAC6
Target Antigen
HDAC6
Clone
2H3
Applications
ICC, ELISA
Concentration
1 mg/mL
Format
Purified
Buffer
Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
Other References
*Seidel C, Schnekenburger M, Dicato M, Diederich M: Histone deacetylase 6 in health and disease. Epigenomics 2015; 7 (1) : 103-118., URL: https://www.ncbi.nlm.nih.gov/pubmed/25687470
Storage Conditions
Store at 2-8°C. Do not freeze.
Specificity
The mouse monoclonal antibody 2H3 recognizes D1 domain of human histone deacetylase 6 (HDAC6; intracellular antigen), amino acids 281-291. Crossreactivity with other species was not tested.
Applications Notes
Immunocytochemistry: Recommended dilution: 5-10 μg/ml.
Isotype
Mouse IgG1 kappa

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