JS-K

JS-K

• CAS Number: 205432-12-8
• UNSPSC Description: JS-K is a NO donor that reacts with glutathione to generate NO at physiological pH[1]. JS-K inhibits proliferation, induces apoptosis, and disrupts the cell cycle of Jurkat T acute lymphoblastic leukemia cells[2].
• Target Antigen: Apoptosis; NO Synthase
• Type: Reference compound
• Related Pathways: Apoptosis;Immunology/Inflammation
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/js-k.html
• Purity: 99.59
• Solubility: DMSO : 36 mg/mL (ultrasonic;warming)
• Smiles: O=C(N1CCN(/[N+]([O-])=N/OC2=CC=C([N+]([O-])=O)C=C2[N+]([O-])=O)CC1)OCC
• Molecular Weight: 384.30
• References & Citations: [1]Shami PJ, et al. JS-K, a glutathione/glutathione S-transferase-activated nitric oxide donor of the diazeniumdiolate class with potent antineoplastic activity. Mol Cancer Ther. 2003 Apr;2(4):409-17.
• Shipping Conditions: Blue Ice
• Storage Conditions: -20°C, 3 years (Powder)
• Clinical Information: No Development Reported