CDK7 Antibody

CAT: 0247-OAAJ07033-100ULSize: 100 µLDry Ice: NoHazardous: No
CAT#:0247-OAAJ07033-100ULSize:100 µL
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
CAS Number
9007-83-4
Gene Aliases
CAK, CAK1, HCAK, MO15, STK1, CDKN7, p39MO15
Gene ID
1022
Swiss Prot
P50613
Accession Number
NP_001310998
Reactivity
Human, Mouse, Rat
Immunogen
Recombinant proteinof human CDK7
Target
Serine/threonine kinase involved in cell cycle control and in RNA polymerase II-mediated RNA transcription. Cyclin-dependent kinases (CDKs) are activated by the binding to a cyclin and mediate the progression through the cell cycle. Each different complex controls a specific transition between 2 subsequent phases in the cell cycle. Required for both activation and complex formation of CDK1/cyclin-B during G2-M transition, and for activation of CDK2/cyclins during G1-S transition (but not complex formation) . CDK7 is the catalytic subunit of the CDK-activating kinase (CAK) complex. Phosphorylates SPT5/SUPT5H, SF1/NR5A1, POLR2A, p53/TP53, CDK1, CDK2, CDK4, CDK6 and CDK11B/CDK11. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation, thus regulating cell cycle progression. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Phosphorylation of POLR2A in complex with DNA promotes transcription initiation by triggering dissociation from DNA. Its expression and activity are constant throughout the cell cycle. Upon DNA damage, triggers p53/TP53 activation by phosphorylation, but is inactivated in turn by p53/TP53; this feedback loop may lead to an arrest of the cell cycle and of the transcription, helping in cell recovery, or to apoptosis. Required for DNA-bound peptides-mediated transcription and cellular growth inhibition.1
Clonality
Polyclonal
Type
Polyclonal Antibody
Applications
WB, IHC
Purification
Immunogen affinity chromatography
Assay Protocol
Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol
Concentration
1 mg/mL
Format
Liquid
Reconstitution
Store at +4C. For long term storage, aliquot and store at -20C. Avoid freeze/thaw cycles.
Molecular Weight
39 kDa
NCBI Gene Symbol
CDK7
Host or Source
Rabbit
Protein Name
Cyclin-dependent kinase 7
Gene Name URL
CDK7
Nucleotide Accession Number
NM_001324069

Related Products

CatalogName
OCOA14449-20UGCDK7 Protein Lysate
OPCD02104-50UGCDK7 Recombinant Protein
OPCD02104-10UGCDK7 Recombinant Protein
OPCD02104-200UGCDK7 Recombinant Protein
OKEH04731-96WCdk7 ELISA Kit (Rat)
OAED00028-100UGOAED00028-100UG - Anti-Cdk7 (MO1) Antibody
OKEH08439-96WCDK7 ELISA Kit (Human)
OKEH05311-96WCDK7 ELISA Kit (Mouse)
OKEH04731Cdk7 ELISA Kit (Rat) (OKEH04731)
OKEH08439CDK7 ELISA Kit (Human) (OKEH08439)

Alternative Products

CatalogName
MBS7118856-01CDK7 Antibody
ABD6559CDK7 Antibody

Popular Products