IOWH-032

CAT: 0804-HY-18337-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-18337-01Size:5 mg
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Description
IOWH-032 is a a synthetic anti-secretory molecule, is a potent CFTR inhibitor with an IC50 value of 8 μM. IOWH-032 also is a anti-diarrheal agent[1][2].
CAS Number
[1191252-49-9]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
CFTR; SARS-CoV
Type
Reference compound
Related Pathways
Anti-infection; Membrane Transporter/Ion Channel
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Infection; Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/IOWH-032.html
Purity
99.63
Solubility
DMSO : ≥ 100 mg/mL
Smiles
BrC1=C(O)C(Br)=CC(C2=NOC(C(NCC3=CC=C(OC4=CC=CC=C4)C=C3)=O)=N2)=C1
Molecular Formula
C22H15Br2N3O4
Molecular Weight
545.18
Precautions
H302, H315, H319, H335
References & Citations
[1]Doyle K, et al. Inhibitors Of The CFTR Chloride Ion Channel As Potential Treatment For Acute Secretory Diarrhea: Development Of 5-membered Heterocycles Suitable For Pre-clinical Evaluation|[2]de Hostos EL, et al. Developing novel antisecretory drugs to treat infectious diarrhea. Future Med Chem. 2011 Aug;3 (10) :1317-25.|[3]Lotti V, et al. CFTR Modulation Reduces SARS-CoV-2 Infection in Human Bronchial Epithelial Cells. Cells. 2022 Apr 15;11 (8) :1347.|[4]Thiagarajah JR, et al. CFTR inhibitors for treating diarrheal disease. Clin Pharmacol Ther. 2012 Sep;92 (3) :287-90.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2

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