LSKL TFA

• Target:

  TGF-beta/Smad

• Related Pathways:

  Stem Cells

• Purity:

  0.9933

• Bioactivity:

  LSKL TFA (H-Leu-Ser-Lys-Leu-NH2 TFA) is a LAP-TGF? derivative and a TGF-?1 antagonist that can cross the blood-brain barrier, inhibits the binding of TSP-1 to LAP and reduces renal interstitial fibrosis and liver fibrosis, inhibits subarachnoid fibrosis by inhibiting TSP-1-mediated TGF-?1 activity, prevents the occurrence of chronic hydrocephalus and improves long-term neurocognitive deficits after subarachnoid hemorrhage.

• Smiles:

  O=C(O)C(F)(F)F.CC(C)C[C@@H](C(N)=O)NC([C@H](CCCCN)NC([C@H](CO)NC([C@@H](N)CC(C)C)=O)=O)=O

• Molecular Formula:

  C23H43F3N6O7

• Molecular Weight:

  572.62

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  2828433-17-4