AMY-101

• Target:

  SARS-CoV|||Others|||Complement System

• Related Pathways:

  Microbiology/Virology|||Immunology/Inflammation|||Others

• Bioactivity:

  AMY-101 is a peptidic inhibitor of the central complement component C3 (KD: 0.5 nM) . AMY-101 shows a favorable anti-inflammatory activity in models with COVID-19 severe pneumonia with systemic hyper inflammation.

• Smiles:

  CC[C@H] (C) [C@H] (NC (=O) [C@H] (N) Cc1ccc (O) cc1) C (=O) N[C@H]1CSSC[C@H] (NC (=O) [C@H] (CCCNC (N) =N) NC (=O) [C@H] (Cc2cnc[nH]2) NC (=O) [C@H] (C) NC (=O) CN (C) C (=O) [C@H] (Cc2c[nH]c3ccccc23) NC (=O) [C@H] (CC (O) =O) NC (=O) [C@H] (CCC (N) =O) NC (=O) [C@H] (Cc2cn (C) c3ccccc23) NC (=O) [C@@H] (NC1=O) C (C) C) C (=O) N (C) [C@@H] ([C@@H] (C) CC) C (N) =O

• Molecular Formula:

  C83H117N23O18S2

• Molecular Weight:

  1789.11

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  1427001-89-5