Lei-Dab7

• Target:

  Potassium Channel

• Related Pathways:

  Membrane transporter/Ion channel

• Bioactivity:

  High affinity, selective KCa2.2 (SK2) channel blocker (Kd = 3.8 nM) . Exhibits >200-fold selectivity for KCa2.2 over KCa2.1, KCa2.3, KCa3.1, IK, Kv and Kir2.1. Increases theta-burst responses and increases LTP in rat hippocampal slices in vitro. Convulsive in vivo.

• Smiles:

  [C@H](CC1=CC=CC=C1)(C(N[C@@H]2C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCN)C(=O)N[C@@]3(C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@]4(C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@](CSSC2)(C(=O)N[C@@]([C@H](CC)C)(C(=O)NCC(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@](CSSC3)(C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CC5=CN=CN5)C(N)=O)=O)CCCCN)=O)[C@H](C)C)=O)CSSC4)[H])[H])[H])[H])[H])=O)NC([C@H](C)N)=O

• Molecular Formula:

  C141H236N46O39S6

• Molecular Weight:

  3392.06

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  1061556-49-7