RAGE antagonist peptide

• Target:

  Beta Amyloid

• Related Pathways:

  Neuroscience

• Bioactivity:

  Receptor for advanced glycation end products (RAGE) antagonist. Blocks S100P, S100A4 and HMGB-1 mediated RAGE activation in vitro and in vivo. Inhibits growth and metastasis of rat glioma tumors. Reduces cell growth and RAGE-mediated NF-?B activity in human PDAC cell lines. Inhibits effects of TDI exposure in BALB/c mice.

• Smiles:

  [C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CC(C)C)C(N)=O)=O)CCC(O)=O)=O)CCCCN)=O)(NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CCC(O)=O)NC(C)=O)=O)CC(C)C)=O)CCCCN)=O)[C@H](C)C)=O)CC(C)C)=O)CCSC)=O)CCC(O)=O

• Molecular Formula:

  C57H101N13O17S

• Molecular Weight:

  1272.56

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  1092460-91-7