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RAGE/SERT-IN-1

CAT: 0931-T72824-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0931-T72824-01Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2766739-35-7
Target
Serotonin Transporter, Others, Beta Amyloid
Related Pathways
Others, Neuroscience
Bioactivity
RAGE/SERT-IN-1 is a potent, orally active inhibitor of advanced glycation end products (RAGE) and serotonin transporter (SERT), with IC50 values of 8.26 μM and 31.09 nM, respectively. It demonstrates significant neuroprotective effects against Aβ25-35-induced neuronal damage and alleviates depressive behavior in mice. RAGE/SERT-IN-1 is useful for research on the comorbidity of Alzheimer's disease and depression [1].
Smiles
CCCCC1=C(N=C(S1)C2CCN(CC2)CCCCC3=CN(C4=C3C=C(C=C4)C#N)C)C5=CC=C(C=C5)OC6=CC=C(C=C6)Cl
Molecular Formula
C38H41ClN4OS
Molecular Weight
637.28
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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