4SC-203

CAT: 0931-T9473-04Size: 25 mgDry Ice: NoHazardous: No

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CAT#:0931-T9473-04Size:25 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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CAS Number

895533-09-2

Target

VEGFR, FLT

Related Pathways

Tyrosine Kinase/Adaptors, Angiogenesis

Purity

0.9984

Bioactivity

4SC-203 is a multi-kinase inhibitor with potential anti-tumor activity. 4SC-203 exhibits unique selectivity for Flt3, Flt3 mutants, Axl, Alk, Fak, VEGF-R2, and Trk receptors in the low nM range.

Smiles

COc1ccc(C)cc1NC(=O)Nc1nc2ccc(Nc3ncnc4cc(OCCCN5CCN(C)CC5)c(OC)cc34)cc2s1

Molecular Formula

C33H38N8O4S

Molecular Weight

642.77

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Chemical Information

4Sc-203

4SC-203 has been used in trials studying the treatment of Acute Myeloid Leukemia.

CAS Number	895533-09-2
PubChem CID	44467821
IUPAC Name	1-(2-methoxy-5-methylphenyl)-3-[6-[[6-methoxy-7-[3-(4-methylpiperazin-1-yl)propoxy]quinazolin-4-yl]amino]-1,3-benzothiazol-2-yl]urea
Molecular Formula	C33H38N8O4S
Molecular Weight	642.8
XLogP	5.3
Topological Polar Surface Area	154
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	11
Rotatable Bond Count	11
Heavy Atom Count	46
Formal Charge	0
Complexity	963

SMILES

CC1=CC(=C(C=C1)OC)NC(=O)NC2=NC3=C(S2)C=C(C=C3)NC4=NC=NC5=CC(=C(C=C54)OC)OCCCN6CCN(CC6)C

InChI

InChI=1S/C33H38N8O4S/c1-21-6-9-27(43-3)26(16-21)37-32(42)39-33-38-24-8-7-22(17-30(24)46-33)36-31-23-18-28(44-4)29(19-25(23)34-20-35-31)45-15-5-10-41-13-11-40(2)12-14-41/h6-9,16-20H,5,10-15H2,1-4H3,(H,34,35,36)(H2,37,38,39,42)

InChIKey

MAFACRSJGNJHCF-UHFFFAOYSA-N

Chemical Structure

2D Structure

CAS: 895533-09-2

CID: 44467821

Formula: C33H38N8O4S

MW: 642.8

Interactive 3D Structure

Loading 3D structure...

View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	642.8
XLogP3	5.3
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	11
Rotatable Bond Count	11
Exact Mass	642.27367290
Monoisotopic Mass	642.27367290
Topological Polar Surface Area	154 Å²
Heavy Atom Count	46
Formal Charge	0
Complexity	963
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

Related Products

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T68480-01	4SC-207
T9901A-1615-01	CAL-203
T7611-01	ODM-203
T71235-01	NITD-203
T68264-01	GNE-203
T81876-01	MAIT-203
T9901A-993-01	NI-203
T35351	GO-203
TP1995	MAIT 203
TP3070-01	MAIT-203 acetate

Alternative Products

Catalog	Name
205802	4SC-203
TRC-S199210-1G	4SC 203
B4106-10	4SC-202
HY-111251	4SC-207

4SC-203

Chemical Information

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