Hydroxychloroquine

CAT: 0931-T9287-01Size: 50 mgDry Ice: NoHazardous: No

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CAT#:0931-T9287-01Size:50 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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CAS Number

118-42-3

Target

Parasite, Autophagy, SARS-CoV, TLR

Related Pathways

Autophagy, Immunology/Inflammation, Microbiology/Virology

Purity

0.9979

Bioactivity

Hydroxychloroquine (2-[[4-[ (7-Chloroquinolin-4-yl) amino]pentyl] (ethyl) amino]ethanol) (HCQ) is an alkalinizing lysosomatropic drug that acts by inducing apoptosis of renal cancer cells in vitro and inhibiting TLR7/9. It is a medication used to prevent and treat malaria, and it's also being studied as an experimental treatment for COVID-19.

Smiles

CCN(CCO)CCCC(C)NC1=CC=NC2=CC(Cl)=CC=C12

Molecular Formula

C18H26ClN3O

Molecular Weight

335.87

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Chemical Information

Hydroxychloroquine

Hydroxychloroquine is an aminoquinoline that is chloroquine in which one of the N-ethyl groups is hydroxylated at position 2. An antimalarial with properties similar to chloroquine that acts against erythrocytic forms of malarial parasites, it is mainly used as the sulfate salt for the treatment of lupus erythematosus, rheumatoid arthritis, and light-sensitive skin eruptions. It has a role as an anticoronaviral agent, an antirheumatic drug, an antimalarial and a dermatologic drug. It is a primary alcohol, an organochlorine compound, an aminoquinoline, a secondary amino compound and a tertiary amino compound. It is functionally related to a chloroquine. It is a conjugate base of a hydroxychloroquine(2+).

CAS Number	118-42-3
PubChem CID	3652
IUPAC Name	2-[4-[(7-chloroquinolin-4-yl)amino]pentyl-ethylamino]ethanol
Molecular Formula	C18H26ClN3O
Molecular Weight	335.9
XLogP	3.6
Topological Polar Surface Area	48.4
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	9
Heavy Atom Count	23
Formal Charge	0
Complexity	331

SMILES

CCN(CCCC(C)NC1=C2C=CC(=CC2=NC=C1)Cl)CCO

InChI

InChI=1S/C18H26ClN3O/c1-3-22(11-12-23)10-4-5-14(2)21-17-8-9-20-18-13-15(19)6-7-16(17)18/h6-9,13-14,23H,3-5,10-12H2,1-2H3,(H,20,21)

InChIKey

XXSMGPRMXLTPCZ-UHFFFAOYSA-N

Chemical Structure

2D Structure

CAS: 118-42-3

CID: 3652

Formula: C18H26ClN3O

MW: 335.9

Interactive 3D Structure

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View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	335.9
XLogP3	3.6
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	9
Exact Mass	335.1764402
Monoisotopic Mass	335.1764402
Topological Polar Surface Area	48.4 Å²
Heavy Atom Count	23
Formal Charge	0
Complexity	331
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	1
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

Alternative Products

Catalog	Name
HY-W031727-01	Hydroxychloroquine
CS-EO-02368	Hydroxychloroquine-d4
HY-B1370-01	Hydroxychloroquine (sulfate)
HY-W031727S1	Hydroxychloroquine-d5
TRC-H916905-25MG	Hydroxychloroquine Dimer
TRC-H916920-25MG	Hydroxychloroquine Diethanol
TRC-C373710-25MG	(R)-Hydroxychloroquine

Hydroxychloroquine

Chemical Information

Alternative Products

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