SKI-178

CAT: 0931-T9014-01Size: 2 mgDry Ice: NoHazardous: No

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CAT#:0931-T9014-01Size:2 mg

Selected

24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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CAS Number

1259484-97-3

Target

S1P Receptor, Apoptosis

Related Pathways

Apoptosis, GPCR/G Protein

Purity

0.992

Bioactivity

SKI-178 is a sphingosine kinase 1 (SphK1) inhibitor with IC50 of 0.1-1.8 μM. It induces prolonged mitosis followed by apoptotic cell death through the intrinsic apoptotic cascade. The sustained activation of CDK1 during prolonged mitosis, mediated by SKI-178 leads to the simultaneous phosphorylation of the prosurvival Bcl-2 family members, Bcl-2 and Bcl-xl, as well as the phosphorylation and subsequent degradation of Mcl-1.

Smiles

COc1ccc(cc1)-c1cc([nH]n1)C(=O)N\N=C(/C)c1ccc(OC)c(OC)c1

Molecular Formula

C21H22N4O4

Molecular Weight

394.42

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

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T40280	JH-XVI-178

Alternative Products

Catalog	Name
BA2877-5.1	SKI-178
JAC48497-01	SKI 178
A22510-50	SKI-178 50mg
A22510-5	SKI-178 5mg
A22510-2	SKI-178 2mg
A22510-500	SKI-178 500mg
A22510-100	SKI-178 100mg
A22510-25	SKI-178 25mg
A22510-10	SKI-178 10mg
A22510-10mM-D	SKI-178 10mM * 1mL in DMSO

SKI-178

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