SKI-178

CAT: 0931-MF-0000727-01Size: 2 mgDry Ice: NoHazardous: No
CAT#:0931-MF-0000727-01Size:2 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1259484-97-3
Target
S1P Receptor|||Apoptosis
Related Pathways
Apoptosis|||GPCR/G Protein
Purity
0.992
Bioactivity
SKI-178 is a sphingosine kinase 1 (SphK1) inhibitor with IC50 of 0.1-1.8 ?M. It induces prolonged mitosis followed by apoptotic cell death through the intrinsic apoptotic cascade. The sustained activation of CDK1 during prolonged mitosis, mediated by SKI-178 leads to the simultaneous phosphorylation of the prosurvival Bcl-2 family members, Bcl-2 and Bcl-xl, as well as the phosphorylation and subsequent degradation of Mcl-1.
Smiles
COc1ccc(cc1)-c1cc([nH]n1)C(=O)N\N=C(/C)c1ccc(OC)c(OC)c1
Molecular Formula
C21H22N4O4
Molecular Weight
394.42
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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Alternative Products

CatalogName
MBS5765137SKI-178
A22510-2SKI-178 2mg
A22510-5SKI-178 5mg
A22510-50SKI-178 50mg
A22510-100SKI-178 100mg
A22510-500SKI-178 500mg
A22510-25SKI-178 25mg
A22510-10SKI-178 10mg
A22510-10mM-DSKI-178 10mM * 1mL in DMSO
334386-01SKI (Ski oncogene, Proto-oncogene c-Ski, SKI)

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