Anticancer agent 65

CAT: 0931-T64179-01Size: 25 mgDry Ice: NoHazardous: No
CAT#:0931-T64179-01Size:25 mg
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CAS Number
2407861-48-5
Target
Others|||MMP|||MDM-2/p53|||Bcl-2 Family|||Apoptosis|||Reactive Oxygen Species
Related Pathways
Proteases/Proteasome|||Immunology/Inflammation|||Apoptosis|||Metabolism|||NF-?B|||Others
Bioactivity
Anticancer agent 65 showed good results in tumour cell lines, especially A549 cells (IC50: 1.07 ?M) . anticancer agent 65 blocked the cell cycle of A549 cells in S phase, induced apoptosis, increased the expression of p53 and p21, and contributed to ROS generation and MMP collapse.
Smiles
C[C@]12[C@@]3(C)[C@@]([C@@]([C@](CCCC(C)(C)O)(C)O)(CC3)[H])([C@H](O)C[C@@]1([C@]4(C)[C@@](CC2)(C(C)(C)[C@@H](OC(=O)C5CCNCC5)CC4)[H])[H])[H]
Molecular Formula
C36H63NO5
Molecular Weight
589.89
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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