Anticancer agent 65

• Target:

  Others|||MMP|||MDM-2/p53|||Bcl-2 Family|||Apoptosis|||Reactive Oxygen Species

• Related Pathways:

  Proteases/Proteasome|||Immunology/Inflammation|||Apoptosis|||Metabolism|||NF-?B|||Others

• Bioactivity:

  Anticancer agent 65 showed good results in tumour cell lines, especially A549 cells (IC50: 1.07 ?M) . anticancer agent 65 blocked the cell cycle of A549 cells in S phase, induced apoptosis, increased the expression of p53 and p21, and contributed to ROS generation and MMP collapse.

• Smiles:

  C[C@]12[C@@]3 (C) [C@@] ([C@@] ([C@] (CCCC (C) (C) O) (C) O) (CC3) [H]) ([C@H] (O) C[C@@]1 ([C@]4 (C) [C@@] (CC2) (C (C) (C) [C@@H] (OC (=O) C5CCNCC5) CC4) [H]) [H]) [H]

• Molecular Formula:

  C36H63NO5

• Molecular Weight:

  589.89

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  2407861-48-5