Anticancer agent 65

• Target :

  Others|||MMP|||MDM-2/p53|||Bcl-2 Family|||Apoptosis|||Reactive Oxygen Species

• Related Pathways :

  Proteases/Proteasome|||Immunology/Inflammation|||Apoptosis|||Metabolism|||NF-?B|||Others

• Bioactivity :

  Anticancer agent 65 showed good results in tumour cell lines, especially A549 cells (IC50: 1.07 ?M) . anticancer agent 65 blocked the cell cycle of A549 cells in S phase, induced apoptosis, increased the expression of p53 and p21, and contributed to ROS generation and MMP collapse.

• Smiles :

  C[C@]12[C@@]3(C)[C@@]([C@@]([C@](CCCC(C)(C)O)(C)O)(CC3)[H])([C@H](O)C[C@@]1([C@]4(C)[C@@](CC2)(C(C)(C)[C@@H](OC(=O)C5CCNCC5)CC4)[H])[H])[H]

• Molecular Formula :

  C36H63NO5

• Molecular Weight :

  589.89

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  2407861-48-5