FGFR-IN-8

• Target:

  Apoptosis|||FGFR|||Others

• Related Pathways:

  Tyrosine Kinase/Adaptors|||Angiogenesis|||Apoptosis|||Others

• Bioactivity:

  FGFR-IN-8 is a potent, orally active FGFR inhibitor that inhibits both wild-type and mutant FGFR. FGFR-IN-8 acts on FGFR1 (IC50<0.5 nM), V564F-FGFR2 (IC5016: 189.1 nM), N549H-FGFR2 (IC50<0.5 nM), V555M-FGFR3 (IC50: 22.6 nM), FGFR3 (IC50<0.5 nM) and FGFR 4 (IC50: 7.30 nM), V555M-FGFR3 (IC50: 22.6 nM), FGFR3 (IC50<0.5 nM) and FGFR 4 (IC50: 7.30 nM) . FGFR-IN-8 induces apoptosis and exhibits anti-cancer effects.

• Smiles:

  N(C1=C(C=CC=N1)C=2N=C(NC3=CN(N=C3)C4CCN(C(C)C)CC4)N=CN2)C5=C(Cl)C(OC)=CC(OC)=C5Cl

• Molecular Formula:

  C27H31Cl2N9O2

• Molecular Weight:

  584.5

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  2640217-64-5