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FGFR-IN-8

CAT: 0931-T64125-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0931-T64125-01Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2640217-64-5
Target
Apoptosis, FGFR, Others
Related Pathways
Tyrosine Kinase/Adaptors, Angiogenesis, Apoptosis, Others
Bioactivity
FGFR-IN-8 is a potent, orally active FGFR inhibitor that inhibits both wild-type and mutant FGFR. FGFR-IN-8 acts on FGFR1 (IC50<0.5 nM), V564F-FGFR2 (IC5016: 189.1 nM), N549H-FGFR2 (IC50<0.5 nM), V555M-FGFR3 (IC50: 22.6 nM), FGFR3 (IC50<0.5 nM) and FGFR 4 (IC50: 7.30 nM), V555M-FGFR3 (IC50: 22.6 nM), FGFR3 (IC50<0.5 nM) and FGFR 4 (IC50: 7.30 nM) . FGFR-IN-8 induces apoptosis and exhibits anti-cancer effects.
Smiles
N(C1=C(C=CC=N1)C=2N=C(NC3=CN(N=C3)C4CCN(C(C)C)CC4)N=CN2)C5=C(Cl)C(OC)=CC(OC)=C5Cl
Molecular Formula
C27H31Cl2N9O2
Molecular Weight
584.5
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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HY-150652FGFR-IN-8
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