Regorafenib mesylate

• Target:

  Others|||c-Kit|||PDGFR|||c-RET|||VEGFR|||FGFR|||Tie-2|||Raf|||Autophagy

• Related Pathways:

  Autophagy|||Tyrosine Kinase/Adaptors|||Others|||Angiogenesis|||Apoptosis|||MAPK

• Bioactivity:

  Regorafenib (BAY 73-4506) mesylate is an orally active multi-target receptor tyrosine kinase inhibitor, inhibiting VEGFR1/2/3 (IC50=13/4.2/46 nM), PDGFR? (IC50: 22 nM), Kit (IC50: 7 nM), RET (IC50: 1.5 nM), and Raf-1 (IC50: 2.5 nM), with potent anti-tumor and anti-angiogenic effects.

• Smiles:

  CS (O) (=O) =O.CNC (=O) c1cc (Oc2ccc (NC (=O) Nc3ccc (Cl) c (c3) C (F) (F) F) c (F) c2) ccn1

• Molecular Formula:

  C22H19ClF4N4O6S

• Molecular Weight:

  578.92

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  835621-08-4