Regorafenib monohydrate

• CAS Number :

  1019206-88-2

• Target :

  C-Kit|||PDGFR|||Tie-2|||Autophagy|||Raf|||FGFR|||c-RET|||VEGFR

• Related Pathways :

  MAPK|||Apoptosis|||Tyrosine Kinase/Adaptors|||Angiogenesis|||Autophagy

• Purity :

  0.9969

• Bioactivity :

  Regorafenib Monohydrate is a novel oral multikinase inhibitor with IC50 values of 13, 4.2, 46, 22, 7, 1.5, 2.5, 28, 19 nM for VEGFR1, murine VEGFR2, murine VEGFR3, PDGFR-?, KIT, RET, RAF-1, B-RAF and B-RAF (V600E) respectively.

• Smiles :

  O.CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)c(F)c2)ccn1

• Molecular Formula :

  C21H17ClF4N4O4

• Molecular Weight :

  500.83

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C