Anticancer agent 64

CAT: 0931-MF-0043268-01Size: 25 mgDry Ice: NoHazardous: No
CAT#:0931-MF-0043268-01Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2387902-92-1
Target
Others|||Apoptosis|||Caspase|||Bcl-2 Family|||PARP
Related Pathways
Others|||Proteases/Proteasome|||Apoptosis|||Chromatin/Epigenetic|||DNA Damage/DNA Repair
Bioactivity
Anticancer agent 64 (compound 5m) exhibits potent cytotoxicity against CCRF-CEM cells with an IC50 value of 2.4 ?M, induces apoptosis by activating caspase 3 and 7 and causing PARP cleavage, and significantly disrupts mitochondrial membrane potential, thereby contributing to its anticancer efficacy [1].
Smiles
C(O)(=O)[C@]12[C@@]([C@@]3([C@@](C)(CC1)[C@@]4(C)[C@](CC3)([C@]5(C)[C@@](CC4)(C(C)(C)C6=C(C5)SC(N)=N6)[H])[H])[H])([C@H](C(C)=C)CC2)[H]
Molecular Formula
C31H46N2O2S
Molecular Weight
510.77
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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