Anticancer agent 64

• Target :

  Others|||Apoptosis|||Caspase|||Bcl-2 Family|||PARP

• Related Pathways :

  Others|||Proteases/Proteasome|||Apoptosis|||Chromatin/Epigenetic|||DNA Damage/DNA Repair

• Bioactivity :

  Anticancer agent 64 (compound 5m) exhibits potent cytotoxicity against CCRF-CEM cells with an IC50 value of 2.4 ?M, induces apoptosis by activating caspase 3 and 7 and causing PARP cleavage, and significantly disrupts mitochondrial membrane potential, thereby contributing to its anticancer efficacy [1].

• Smiles :

  C(O)(=O)[C@]12[C@@]([C@@]3([C@@](C)(CC1)[C@@]4(C)[C@](CC3)([C@]5(C)[C@@](CC4)(C(C)(C)C6=C(C5)SC(N)=N6)[H])[H])[H])([C@H](C(C)=C)CC2)[H]

• Molecular Formula :

  C31H46N2O2S

• Molecular Weight :

  510.77

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  2387902-92-1