NRX-252114

• Target :

  Molecular Glues|||Wnt/beta-catenin

• Related Pathways :

  PROTAC|||Stem Cells|||Cytoskeletal Signaling

• Purity :

  0.997

• Bioactivity :

  NRX-252114 (NRX252114) induces degradation of mutant ?-catenin NRX-252114 is a potent enhancer of the interaction of ?-catenin with the homologous E3 ligase SCF?-TrCP, and is able to enhance the binding of pSer33/S37A ?-catenin to ?-TrCP with an EC50 of 6.5 nM and a Kd of 0.4 nM. Kd is 0.4 nM.

• Smiles :

  S(C1=C(C(=O)N2CC=3C(C2)=CC=CC3C#N)C(=O)NC(C(F)(F)F)=C1)C4=C(Cl)C=CC=C4Cl

• Molecular Formula :

  C22H12Cl2F3N3O2S

• Molecular Weight :

  510.32

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  2763260-39-3