NRX-252114

• Target:

  Molecular Glues|||Wnt/beta-catenin

• Related Pathways:

  PROTAC|||Stem Cells|||Cytoskeletal Signaling

• Purity:

  0.997

• Bioactivity:

  NRX-252114 (NRX252114) induces degradation of mutant ?-catenin NRX-252114 is a potent enhancer of the interaction of ?-catenin with the homologous E3 ligase SCF?-TrCP, and is able to enhance the binding of pSer33/S37A ?-catenin to ?-TrCP with an EC50 of 6.5 nM and a Kd of 0.4 nM. Kd is 0.4 nM.

• Smiles:

  S (C1=C (C (=O) N2CC=3C (C2) =CC=CC3C#N) C (=O) NC (C (F) (F) F) =C1) C4=C (Cl) C=CC=C4Cl

• Molecular Formula:

  C22H12Cl2F3N3O2S

• Molecular Weight:

  510.32

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  2763260-39-3