Products for Research Use Only
RegisterLogin

NRX-252114

CAT: 0931-T63516-01Size: 1 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0931-T63516-01Size:1 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
CAS Number
2763260-39-3
Target
Molecular Glues, Wnt/beta-catenin
Related Pathways
PROTAC, Stem Cells, Cytoskeletal Signaling
Purity
0.997
Bioactivity
NRX-252114 (NRX252114) induces degradation of mutant β-catenin NRX-252114 is a potent enhancer of the interaction of β-catenin with the homologous E3 ligase SCFβ-TrCP, and is able to enhance the binding of pSer33/S37A β-catenin to β-TrCP with an EC50 of 6.5 nM and a Kd of 0.4 nM. Kd is 0.4 nM.
Smiles
S(C1=C(C(=O)N2CC=3C(C2)=CC=CC3C#N)C(=O)NC(C(F)(F)F)=C1)C4=C(Cl)C=CC=C4Cl
Molecular Formula
C22H12Cl2F3N3O2S
Molecular Weight
510.32
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Related Products

CatalogName
T63730-01NRX-103095
T63427-01NRX-103094
T62184-01NRX-2663
T60031-01NRX-1933
T70907-01NRX-204647
T75133-01NRX-0492
T61172-01NRX-1532
T9182-01NRX-252262
T6208-01AS-252424
T10575-01BMY-25271

Alternative Products

CatalogName
BA9143-10NRX-252114
7990/25NRX 252114
M35723-01NRX-252114 B
BA9145-5NRX-2663
BA9146-5NRX-103095
BA9141-10NRX-103094
BA9140-5.1NRX-252262
BA8837-10NRX-0492
HY-144982-01NRX-1532
MBS5813449NRX-204647

Popular Products