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Top/HDAC-IN-1

CAT: 0931-T63509-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0931-T63509-01Size:25 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Target
Apoptosis, Others, Topoisomerase, HDAC
Related Pathways
DNA Damage/DNA Repair, Others, Apoptosis, Chromatin/Epigenetic
Bioactivity
Top/HDAC-IN-1 is a dual topoisomerase (Top) /HDAC inhibitor that acts on HDAC1 (IC50: 18 nM), HDAC2 (IC50: 230 nM), HDAC3 (IC50: 790 nM), HDAC6 (IC50: 87 nM) and HDAC8 (IC50: 5250 nM) . Top/HDAC-IN-1 exhibited potent antitumor effects on HCT116 cells (IC50: 180 nM), blocked the cell cycle of HCT116 cells in G2 phase, and effectively induced apoptosis.
Molecular Formula
C29H27N5O4
Molecular Weight
509.56
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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