(E/Z) -BIX02188

CAT: 0931-T6324-06Size: 25 mgDry Ice: NoHazardous: No

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CAT#:0931-T6324-06Size:25 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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CAS Number

1094614-84-2

Target

TGF-beta/Smad, ERK, MEK, Others

Related Pathways

MAPK, Others, Stem Cells

Purity

0.9921

Bioactivity

BIX02188 is a specific MEK5 inhibitor (IC50: 4.3 nM), also inhibits ERK5 catalytic activity (IC50: 810 nM), and does not inhibit closely related kinases MEK1/2, JNK2, and ERK2.

Smiles

CN(C)Cc1cccc(NC(=C2C(=O)Nc3cc(ccc23)C(N)=O)c2ccccc2)c1

Molecular Formula

C25H24N4O2

Molecular Weight

412.48

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Chemical Information

(Z)-3-(((3-((dimethylamino)methyl)phenyl)amino)(phenyl)methylene)-2-oxoindoline-6-carboxamide

See also: Bix-02188 (annotation moved to).

CAS Number	1094614-84-2
PubChem CID	135398492
IUPAC Name	3-[N-[3-[(dimethylamino)methyl]phenyl]-C-phenylcarbonimidoyl]-2-hydroxy-1H-indole-6-carboxamide
Molecular Formula	C25H24N4O2
Molecular Weight	412.5
XLogP	3.9
Topological Polar Surface Area	94.7
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	6
Heavy Atom Count	31
Formal Charge	0
Complexity	645

SMILES

CN(C)CC1=CC(=CC=C1)N=C(C2=CC=CC=C2)C3=C(NC4=C3C=CC(=C4)C(=O)N)O

InChI

InChI=1S/C25H24N4O2/c1-29(2)15-16-7-6-10-19(13-16)27-23(17-8-4-3-5-9-17)22-20-12-11-18(24(26)30)14-21(20)28-25(22)31/h3-14,28,31H,15H2,1-2H3,(H2,26,30)

InChIKey

WGPXKFOFEXJMBD-UHFFFAOYSA-N

Chemical Structure

2D Structure

CAS: 1094614-84-2

CID: 135398492

Formula: C25H24N4O2

MW: 412.5

Interactive 3D Structure

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View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	412.5
XLogP3	3.9
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	6
Exact Mass	412.18992602
Monoisotopic Mass	412.18992602
Topological Polar Surface Area	94.7 Å²
Heavy Atom Count	31
Formal Charge	0
Complexity	645
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

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HY-107622	(E/Z) -BIX02188
BA6439-10	BIX02188
A10150-25	BIX02188 25mg
A10150-1	BIX02188 1mg
GTR19163677-01	BIX02188 (c)
A10150-10	BIX02188 10mg

(E/Z) -BIX02188

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