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Axl-IN-10

CAT: 0931-T63154-03Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0931-T63154-03Size:100 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2487649-61-4
Target
Others, TAM Receptor
Related Pathways
Others, Tyrosine Kinase/Adaptors
Bioactivity
Axl-IN-10 is a potent inhibitor of AXL (IC50: 5 nM) .Axl-IN-10 has good pharmacokinetic properties in animals and excellent transmembrane properties.Axl-IN-10 can be used to study proliferative, allergic, autoimmune, inflammatory, transplant rejection, cancer or other mammalian diseases.
Smiles
O=C1N(N2C(=C1C(NC3=CC=C(C=C3)C=4C=5C(N(C)C4)=NC=NC5N)=O)CCCC2)C6=CC=CC=C6
Molecular Formula
C27H25N7O2
Molecular Weight
479.53
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Chemical Information

Axl-IN-10
CAS Number2487649-61-4
PubChem CID155108804
IUPAC NameN-[4-(4-amino-7-methylpyrrolo[2,3-d]pyrimidin-5-yl)phenyl]-2-oxo-1-phenyl-4,5,6,7-tetrahydropyrazolo[1,5-a]pyridine-3-carboxamide
Molecular FormulaC27H25N7O2
Molecular Weight479.5
XLogP3.4
Topological Polar Surface Area109
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count6
Rotatable Bond Count4
Heavy Atom Count36
Formal Charge0
Complexity879
SMILES
CN1C=C(C2=C(N=CN=C21)N)C3=CC=C(C=C3)NC(=O)C4=C5CCCCN5N(C4=O)C6=CC=CC=C6
InChI
InChI=1S/C27H25N7O2/c1-32-15-20(22-24(28)29-16-30-25(22)32)17-10-12-18(13-11-17)31-26(35)23-21-9-5-6-14-33(21)34(27(23)36)19-7-3-2-4-8-19/h2-4,7-8,10-13,15-16H,5-6,9,14H2,1H3,(H,31,35)(H2,28,29,30)
InChIKey
TUEAZGCOJDXLNO-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Axl-IN-10
CAS: 2487649-61-4
CID: 155108804
Formula: C27H25N7O2
MW: 479.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight479.5
XLogP33.4
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count6
Rotatable Bond Count4
Exact Mass479.20697307
Monoisotopic Mass479.20697307
Topological Polar Surface Area109 Ų
Heavy Atom Count36
Formal Charge0
Complexity879
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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MBS5805828Axl-IN-10
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MBS6407950-01AXL (AXL Oncogene, AXL Receptor Tyrosine Kinase, AXL Transforming Gene, JTK11, UFO) (AP)
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