ZLMT-12

• Target :

  Cholinesterase (ChE) |||Apoptosis|||Others|||CDK

• Related Pathways :

  Apoptosis|||Others|||Neuroscience|||Cell Cycle/Checkpoint

• Bioactivity :

  ZLMT-12 (compound 35) is a tacrine derivative and a potent inhibitor of CDK2 (IC50: 0.011 ?M) and CDK9 (IC50: 0.002 ?M) . ZLMT-12 weakly inhibits AChE (IC50: 19.023 ?M) and BuChE (IC50: 2.768 ?M) . ZLMT-12 has anti-proliferative activity and low cytotoxicity. ZLMT-12 blocks the cell cycle in S-phase and G2/M-phase and induces apoptosis.

• Molecular Formula :

  C26H31ClN6O

• Molecular Weight :

  479.02

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C