ZLMT-72

CAT: 0013-GTR19273904-01Size: 50 mgDry Ice: NoHazardous: No

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CAT#:0013-GTR19273904-01Size:50 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

ZLMT-72 is an orally active dual inhibitor of CDK2 and CDK9, with IC50 values of 0.741 nM and 1.03 nM, respectively. It shows excellent selectivity in kinase profiling and cholinesterase inhibition activity assays. ZLMT-72 exhibits significant antiproliferative effects on colorectal cancer (CRC) cell line HCT116 (GI50 < 0.1 nM) . This compound induces apoptosis by inhibiting the phosphorylation of retinoblastoma protein and RNA polymerase II, leading to the downregulation of anti-apoptotic proteins (Mcl-1 and XIAP) . ZLMT-72 is suitable for colorectal cancer (CRC) research.

Storage Conditions

-20°C

Notes

For research use only.

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Alternative Products

Catalog	Name
HY-179633	ZLMT-72
HY-151436	ZLMT-12
ABC-TC0036	A-72
138595-AF	TAG-72 (Tumor-associated Glycoprotein 72, TAG 72)
172153-01	TAG-72 (CA 72.4, Tumor Associated GlycoProtein 72)
MBS6122470-01	TAG-72 (Tumor-associated Glycoprotein 72, TAG 72) (PE)
138595-AF-Biotin	TAG-72 (Tumor-associated Glycoprotein 72, TAG 72) (Biotin)
MBS6122465-01	TAG-72 (Tumor-associated Glycoprotein 72, TAG 72) (AP)
138595-AF-HRP	TAG-72 (Tumor-associated Glycoprotein 72, TAG 72) (HRP)
138595-AF-APC	TAG-72 (Tumor-associated Glycoprotein 72, TAG 72) (APC)

ZLMT-72

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