MK-2206

• Target:

  Akt|||Apoptosis|||Autophagy|||Others

• Related Pathways:

  PI3K/Akt/mTOR signaling|||Others|||Autophagy|||Cytoskeletal Signaling|||Apoptosis

• Bioactivity:

  MK-2206 is an orally active, highly selective, metabotropic Akt inhibitor that targets Akt1 [IC50: 8 nM], Akt2 [IC50: 12 nM], and Akt3 [IC50: 65 nM]. Many breast cancer cell lines, PIK3CA mutants, and PTEN-losing cell lines are sensitive to MK-2206, which exhibits anti-cancer effects.

• Smiles:

  Cl.NC1 (CCC1) c1ccc (cc1) -c1nc2ccn3c (n[nH]c3=O) c2cc1-c1ccccc1

• Molecular Formula:

  C25H22ClN5O

• Molecular Weight:

  443.94

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  1032349-77-1