MK-2206

CAT: 0931-T62609-01Size: 25 mgDry Ice: NoHazardous: No
CAT#:0931-T62609-01Size:25 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1032349-77-1
Target
Akt|||Apoptosis|||Autophagy|||Others
Related Pathways
PI3K/Akt/mTOR signaling|||Others|||Autophagy|||Cytoskeletal Signaling|||Apoptosis
Bioactivity
MK-2206 is an orally active, highly selective, metabotropic Akt inhibitor that targets Akt1 [IC50: 8 nM], Akt2 [IC50: 12 nM], and Akt3 [IC50: 65 nM]. Many breast cancer cell lines, PIK3CA mutants, and PTEN-losing cell lines are sensitive to MK-2206, which exhibits anti-cancer effects.
Smiles
Cl.NC1(CCC1)c1ccc(cc1)-c1nc2ccn3c(n[nH]c3=O)c2cc1-c1ccccc1
Molecular Formula
C25H22ClN5O
Molecular Weight
443.94
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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