MK-2206

• Target :

  Akt|||Apoptosis|||Autophagy|||Others

• Related Pathways :

  PI3K/Akt/mTOR signaling|||Others|||Autophagy|||Cytoskeletal Signaling|||Apoptosis

• Bioactivity :

  MK-2206 is an orally active, highly selective, metabotropic Akt inhibitor that targets Akt1 [IC50: 8 nM], Akt2 [IC50: 12 nM], and Akt3 [IC50: 65 nM]. Many breast cancer cell lines, PIK3CA mutants, and PTEN-losing cell lines are sensitive to MK-2206, which exhibits anti-cancer effects.

• Smiles :

  Cl.NC1(CCC1)c1ccc(cc1)-c1nc2ccn3c(n[nH]c3=O)c2cc1-c1ccccc1

• Molecular Formula :

  C25H22ClN5O

• Molecular Weight :

  443.94

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  1032349-77-1