BACE1-IN-5

CAT: 0931-MF-0004562-01Size: 25 mgDry Ice: NoHazardous: No
CAT#:0931-MF-0004562-01Size:25 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2581114-83-0
Target
Beta Amyloid|||Beta-Secretase|||BACE
Related Pathways
Neuroscience
Bioactivity
BACE1-IN-5 (Compound 15), a potent ?-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitor, demonstrates significant efficacy with an IC50 of 9.1 nM for BACE1 inhibition and an impressive IC50 of 0.82 nM against cellular amyloid-? (A?) production. Additionally, it is engineered to enhance hERG inhibition and P-gp efflux, indicating its optimized medicinal chemistry profile [1].
Smiles
C[C@]1(C[C@@H](C(F)(F)F)SC(N)=N1)C2=CC(NC(=O)C=3C=NC(OCF)=CN3)=CC=C2F
Molecular Formula
C18H16F5N5O2S
Molecular Weight
461.41
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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