BACE1-IN-5

• Target :

  Beta Amyloid|||Beta-Secretase|||BACE

• Related Pathways :

  Neuroscience

• Bioactivity :

  BACE1-IN-5 (Compound 15), a potent ?-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitor, demonstrates significant efficacy with an IC50 of 9.1 nM for BACE1 inhibition and an impressive IC50 of 0.82 nM against cellular amyloid-? (A?) production. Additionally, it is engineered to enhance hERG inhibition and P-gp efflux, indicating its optimized medicinal chemistry profile [1].

• Smiles :

  C[C@]1(C[C@@H](C(F)(F)F)SC(N)=N1)C2=CC(NC(=O)C=3C=NC(OCF)=CN3)=CC=C2F

• Molecular Formula :

  C18H16F5N5O2S

• Molecular Weight :

  461.41

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  2581114-83-0