BACE1-IN-5

• Target:

  Beta Amyloid|||Beta-Secretase|||BACE

• Related Pathways:

  Neuroscience

• Bioactivity:

  BACE1-IN-5 (Compound 15), a potent ?-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitor, demonstrates significant efficacy with an IC50 of 9.1 nM for BACE1 inhibition and an impressive IC50 of 0.82 nM against cellular amyloid-? (A?) production. Additionally, it is engineered to enhance hERG inhibition and P-gp efflux, indicating its optimized medicinal chemistry profile [1].

• Smiles:

  C[C@]1 (C[C@@H] (C (F) (F) F) SC (N) =N1) C2=CC (NC (=O) C=3C=NC (OCF) =CN3) =CC=C2F

• Molecular Formula:

  C18H16F5N5O2S

• Molecular Weight:

  461.41

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  2581114-83-0