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Anticancer agent 82

CAT: 0931-T61746Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0931-T61746Size:100 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2319587-80-7
Target
Others, Proteasome
Related Pathways
Others, Proteases/Proteasome, Ubiquitination
Bioactivity
Anticancer agent 82 is a FiVe1 derivative, an orally active and selective anticancer agent. FiVe1 binds type III intermediate filament protein vimentin (VIM), to induce hyperphosphorylation of Ser56, resulting selective disruption of mitosis and multinucleation in transformed VIM-expressing mesenchymal cancer cells. Anticancer agent 82 shows better oral bioavailability and pharmacokinetic profiles than FiVe1 [1].
Smiles
COc1cc(Cl)cc(c1)N1CCN(CC1)c1cnnc2c(Cl)cccc12
Molecular Formula
C19H18Cl2N4O
Molecular Weight
389.28
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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