EZH2-IN-14
CAT:
804-HY-148458-03
Size:
25 mg
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
EZH2-IN-14
- CAS Number: 1979157-17-9
- UNSPSC Description: EZH2-IN-14 is a selective EZH2 (Histone Methyltransferase) inhibitor with an IC50 of 12 nM. EZH2-IN-14 inhibits the methyltransferase activity of EZH2/PRC2 (that is, reducing H3K27me3). EZH2-IN-14 shows >200-fold selective for EZH2 over the highly homologous H3K27 methyltransferase EZH1[1].
- Target Antigen: Histone Methyltransferase
- Type: Reference compound
- Related Pathways: Epigenetics
- Applications: Cancer-programmed cell death
- Field of Research: Cancer
- Assay Protocol: https://www.medchemexpress.com/ezh2-in-14.html
- Solubility: DMSO : 125 mg/mL (ultrasonic;warming;heat to 60°C)
- Smiles: O=C(C1=CC(C2=CC=C(N3CCN(C(C)C)CC3)N=C2)=CC4=C1C=NN4C(C)C)NCC5=C(C)C=C(C)NC5=O
- Molecular Weight: 541.69
- References & Citations: [1]Anqi Ma, et al. Discovery of a first-in-class EZH2 selective degrader. Nat Chem Biol. 2020 Feb;16(2):214-222.
- Shipping Conditions: Blue Ice
- Clinical Information: No Development Reported