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UNC-CA359

CAT: 0931-T61077-03Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0931-T61077-03Size:100 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2676156-05-9
Target
EGFR, Others
Related Pathways
Others, JAK/STAT signaling, Angiogenesis, Tyrosine Kinase/Adaptors
Bioactivity
UNC-CA359 is a highly potent inhibitor of the epidermal growth factor receptor (EGFR), demonstrating an IC50 value of 18 nM. With strong anti-tumor activity, UNC-CA359 holds significant potential for chordoma research [1].
Smiles
N(C=1C2=C(C=C(OC)C(OC)=C2)N=CN1)C3=CC(C#C)=C(Cl)C=C3
Molecular Formula
C18H14ClN3O2
Molecular Weight
339.78
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Chemical Information

Unc-CA359
CAS Number2676156-05-9
PubChem CID164886643
IUPAC NameN-(4-chloro-3-ethynylphenyl)-6,7-dimethoxyquinazolin-4-amine
Molecular FormulaC18H14ClN3O2
Molecular Weight339.8
XLogP4.2
Topological Polar Surface Area56.3
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count5
Rotatable Bond Count5
Heavy Atom Count24
Formal Charge0
Complexity468
SMILES
COC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC(=C(C=C3)Cl)C#C)OC
InChI
InChI=1S/C18H14ClN3O2/c1-4-11-7-12(5-6-14(11)19)22-18-13-8-16(23-2)17(24-3)9-15(13)20-10-21-18/h1,5-10H,2-3H3,(H,20,21,22)
InChIKey
KQFANGBOVPXOEP-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Unc-CA359
CAS: 2676156-05-9
CID: 164886643
Formula: C18H14ClN3O2
MW: 339.8
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight339.8
XLogP34.2
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count5
Rotatable Bond Count5
Exact Mass339.0774544
Monoisotopic Mass339.0774544
Topological Polar Surface Area56.3 Ų
Heavy Atom Count24
Formal Charge0
Complexity468
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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