UNC 1025

CAT: 0931-MF-0095119-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0931-MF-0095119-01Size:1 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1350549-36-8
Target
Others|||TAM Receptor
Related Pathways
Others|||Tyrosine Kinase/Adaptors
Purity
0.996
Bioactivity
UNC1062 is a highly selective tyrosine kinase inhibitor that specifically targets MERTK. This compound effectively suppresses MERTK-mediated downstream signaling, induces apoptosis in cell cultures, reduces colony formation in soft agar, and inhibits invasion of melanoma cells. Notably, UNC1062 demonstrates potent inhibition of MERTK kinase activity, with an IC50 of 1.1 nM and a Morrison Ki of 0.33 nM. It also displays specificity within the TAM family, exhibiting IC50 values of 60 nM for TYRO3 and 85 nM for AXL [1].
Smiles
CCCCNc1ncc2c(nn([C@H]3CC[C@H](O)CC3)c2n1)-c1ccc(cc1)S(=O)(=O)N1CCOCC1
Molecular Formula
C25H34N6O4S
Molecular Weight
514.64
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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