Products for Research Use Only
RegisterLogin

Gefitinib-based PROTAC 3

CAT: 0931-T5437-01Size: 2 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0931-T5437-01Size:2 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
CAS Number
2230821-27-7
Target
EGFR, PROTACs
Related Pathways
JAK/STAT signaling, Angiogenesis, Tyrosine Kinase/Adaptors, PROTAC
Purity
0.9825
Bioactivity
Gefitinib-based PROTAC 3, which connects an EGFR binding element to a VHL ligand via a linker, induces EGFR degradation with DC50s of 11.7 nM and 22.3 nM in HCC827 (exon 19 del) and H3255 (L858R mutation) cells, respectively[1].
Smiles
N(C=1C2=C(C=C(OC)C(OCCCCCOCCOCCC(N[C@H](C(=O)N3[C@H](C(NCC4=CC=C(C=C4)C=5SC=NC5C)=O)C[C@@H](O)C3)[C@](C)(C)C)=O)=C2)N=CN1)C6=CC(Cl)=C(F)C=C6
Molecular Formula
C47H57ClFN7O8S
Molecular Weight
934.51
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Related Products

CatalogName
T1181-01Gefitinib
TMIJ-0147-01Gefitinib-d6
T63630-01Gefitinib dihydrochloride
T11384Gefitinib-d8
T1181L-01Gefitinib hydrochloride
T11385-01Gefitinib N-oxide
T16369-01O-Desmethyl gefitinib
T65550Gefitinib analog III
T40785-01Gefitinib impurity 1
T89359-01PROTAC CRBN ligand-3

Alternative Products

CatalogName
MBS3603574-01Gefitinib-based PROTAC 3
A19093-100Gefitinib-based PROTAC 3 100mg
A19093-10Gefitinib-based PROTAC 3 10mg

Popular Products