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Gefitinib

CAT: 0931-T1181-01Size: 1 mL - 10 mM (in DMSO)Dry Ice: NoHazardous: No
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CAT#:0931-T1181-01Size:1 mL - 10 mM (in DMSO)
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
184475-35-2
Target
Apoptosis, EGFR, Autophagy, Tyrosine Kinases
Related Pathways
JAK/STAT signaling, Angiogenesis, Autophagy, Tyrosine Kinase/Adaptors, Apoptosis
Purity
>99.99%
Bioactivity
Gefitinib (ZD1839) is an EGFR first-generation inhibitor with oral activity that inhibits the EGFR 19 Del and L858R mutations. Gefitinib has antitumor activity and is used for the treatment of EGFR-mutated non-small-cell lung cancers. Gefitinib administration RESULTS in the development of the EGFR C797S resistance mutation.
Smiles
N(C=1C2=C(C=C(OC)C(OCCCN3CCOCC3)=C2)N=CN1)C4=CC(Cl)=C(F)C=C4
Molecular Formula
C22H24ClFN4O3
Molecular Weight
446.9
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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