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ML 297

CAT: 0931-T4664-02Size: 1 mL - 10 mM (in DMSO)Dry Ice: NoHazardous: No
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CAT#:0931-T4664-02Size:1 mL - 10 mM (in DMSO)
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1443246-62-5
Target
Potassium Channel
Related Pathways
Membrane transporter/Ion channel
Purity
0.9785
Bioactivity
ML 297 is a selective Kir3.1/3.2 (GIRK1/2) channel activator (IC50 values are 160, 887 and 914 nM for GIRK1/2, GIRK1/4 and GIRK1/3 respectively) . ML 297 exhibits no effect on GIRK2, GIRK2/3, Kir2.1 and Kv7.4 channels, and has minimal effect on a panel of other ion channels, receptors and transporters.
Smiles
Cc1cc(NC(=O)Nc2ccc(F)c(F)c2)n(n1)-c1ccccc1
Molecular Formula
C17H14F2N4O
Molecular Weight
328.32
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Chemical Information

ML297

ML297 is an organic molecular entity. It has a role as a potassium channel opener.

CAS Number1443246-62-5
PubChem CID56642816
IUPAC Name1-(3,4-difluorophenyl)-3-(5-methyl-2-phenylpyrazol-3-yl)urea
Molecular FormulaC17H14F2N4O
Molecular Weight328.32
XLogP3.4
Topological Polar Surface Area59
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count4
Rotatable Bond Count3
Heavy Atom Count24
Formal Charge0
Complexity433
SMILES
CC1=NN(C(=C1)NC(=O)NC2=CC(=C(C=C2)F)F)C3=CC=CC=C3
InChI
InChI=1S/C17H14F2N4O/c1-11-9-16(23(22-11)13-5-3-2-4-6-13)21-17(24)20-12-7-8-14(18)15(19)10-12/h2-10H,1H3,(H2,20,21,24)
InChIKey
IEKSMUSSYJUQMY-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of ML297
CAS: 1443246-62-5
CID: 56642816
Formula: C17H14F2N4O
MW: 328.32
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight328.32
XLogP33.4
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count4
Rotatable Bond Count3
Exact Mass328.11356741
Monoisotopic Mass328.11356741
Topological Polar Surface Area59 Ų
Heavy Atom Count24
Formal Charge0
Complexity433
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Related Products

CatalogName
T70157-01GGTI-297
T28628-01RVX-297
T27749-01KRP-297
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TMPY-02819-01CD20 Protein, Human, Recombinant (aa 213-297, His)
T22990ML-090
T22999-01ML-243
T22998-01ML-233
T8966-01ML-298
T86911-01ML-T7

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