Capmatinib 2HCl

CAT: 0931-T4260-01Size: 2 mgDry Ice: NoHazardous: No
CAT#:0931-T4260-01Size:2 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1197376-85-4
Target
C-Met/HGFR|||Apoptosis
Related Pathways
Apoptosis|||Tyrosine Kinase/Adaptors
Purity
>99.99%
Bioactivity
Capmatinib 2HCl (INC-280 2HCl) is a novel, ATP-competitive inhibitor of c-MET kinase with an IC50 with 0.13 nM.Capmatinib 2HCl exhibits picomolar enzymatic potency and is highly specific for c-MET with more than 10, 000-fold selectivity over a large panel of human kinases. This inhibitor potently blocks c-MET phosphorylation and activation of its key downstream effectors in c-MET-dependent tumor cell lines. As a result, Capmatinib 2HCl potently inhibits c-MET-dependent tumor cell proliferation and migration and effectively induces apoptosis in vitro.
Smiles
Cl.Cl.CNC(=O)c1ccc(cc1F)-c1cnc2ncc(Cc3ccc4ncccc4c3)n2n1
Molecular Formula
C23H19Cl2FN6O
Molecular Weight
485.34
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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